Effect of Solanine on Arthritis Symptoms in Postmenopausal Female Albino Rats

Solanine is a toxic compound produced in nightshades family as potato,tomato and eggplant when exposed to light.The current study was carried out on 18 femal postmenopausal albino rats to investigate the effect of solanine on the symptoms of rheumatoid arthritis.Animals were classified into 3 groups feeding on balanced diet only (GI) or replaced by twothird with small pieces of diseased potatoes for 2 and 4 weeks (GII,GIII) respectively . Serum levels of arthritic biomarkers were investigated as the estimation of erythrocytes sedimentation rate ( ESR) , C-Reactive Protein (CRP), malondialdehyde (MDA),Tumor necrosis factor-α (TNFα),Interleukin-6( IL-6) and Immunoglobuline G (IgG) were determined in all groups. There was a significant positive increase in the levels of ESR, CRP , MDA , TNF-α, IL-6 , and IgG among different groups depending on potatoes intake. There was positive correlation between the serum levels of CRP and TNF-α ,Il-6 and IgG.However, a non significantly positive correlation between serum level of CRP and the level of MDA was observed. The data of the present study showed that old age and postmenopausal suffering from arthritis and joint swollen must eliminat or avoid the nightshades plants to alleviate the joint pain and also decrease the destruction of the tissues.